Genedelivery相关论文
Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nano
The functionality of DNA biomacromolecules has been widely excavated,as therapeutic drugs,carriers,and functionalized mo......
Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex na
Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration o......
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Introduction: Gene therapy is a new potential therapeutic strategy for cancer.Recently, minicircle DNA(mcDNA) and the sm......
Large Pore-sized Ultrasmall Mesoporous Organosilica Nanoparticles:Micelle/precursor Co-templating As
The synthesis of ultrasmall mesoporous nanoparticles(e.g.,6 nm)is of great significance for the encapsulation and direct......
Gold nanoparticles coated by polyethylenimine-g-bovine serum albumin with different morphologies for
One of the biggest barriers for the further application of non-viral gene vectors is their unsatisfied gene transfection......
Ultra-small,glutathione responsive nanocaplets prepared via templated-polymerization for gene and pr
Advances in nanotechnology-based medicine offer excellent opportunity to design nanosized entities comprising pharmaceut......
Development of effective gene vectors is critical to the success of gene therapy[1].Up-to-date,readily-available gene ve......
Gene or drug carriers with charge-conversional properties were considered to be appealing and practical for in vivo appl......
Chemically conjugating poly(amidoamine) with chondroitin sulfate to promote CD44-mediated endocytosi
Therapeutic strategies based on the modulation of microRNA activity possess much promise in cancer gene therapy.MieroRNA......
Biodegradable poly(ethylene glycol) methyl ether acrylate-b-poly(L-lysine)-b-poly(L-histidine) tribl
The development of biodegradable cationic polymers for gene delivery is desirable to circumvent the drawbacks of the vir......
Preparation of PEGylated chelator-stabilized calcium phosphate nanoparticles for liver-targeted deli
Calcium phosphate (CaP) precipitates were developed as a transfection method for DNA in the 1970s [1].This procedure is ......
Improving gene transfection efficacy of low generation dendrimers through specific hydrogen-bond rec
Cationic polymers usually form nanoparticles with DNA or siRNA via ionic interactions.These nanoparticles are easily des......
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Reduction-Sensitive Non-Viral Gene Vectors Based on Thioctic Acid-Substituted Low Molecular Weight P
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Galactosylated Poly(ethylene glycol) Methacrylate-s-N-3-Guanidinopropyl Methacrylamide as siRNA Carr
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Polycationic gene delivery system was widely used for cancer therapy.Polycations with high positive potentials exhibited......
Many types of materials have been used to prepare nanoparticles for drug delivery.Among these materials,proteins are reg......
Graphene and graphene oxide have been extensively explored as drug and gene carriers due to their unique properties:two-......
Cucurbit[7]uril (CB[7]),an important member of cucurbit[n]uril could form inclusion complexes with many guest molecules ......
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Construction of Serum-resistance Cationic Polymer α-CD-PAMAM and evaluation of its performances as G
Polyamidoamine(PAMAM)dendrimers as synthetic gene vectors have been proved to be efficient gene delivery systems.In this......
The regulatory T cells(Tregs)are important key regulators of the immune system.The decrease of Tregs or loss of their fu......
Grene therapy is an attractive approach for the causal treatment of diseases associated with genetic malfunction.Critica......
Efficient antisense oligonucleotide delivery via non-covalent complexes of folic acid and modified p
In the field of gene delivery,the development of vectors with high transfection efficiency and low toxicity is of critic......
Cationic lipidoids have potential applications in the field of gene delivery due to their unique properties.We use combi......
Polymer based gene delivery systems have been widely studied for their safety and simple preparation compared with viral......
Recently,a substantial number of studies focused on gene therapy and nonviral gene delivery vectors [1,2].The REDV seque......
Hydrophobic N-acetyl-L-leucine grafted polyethylenimine as an efficient carrier for DNAzyme delivery
Aurora kinase A has been demonstrated to be involved in the malignant progression of many types of cancer,as its amplifi......
A polyethylenimine derivative-based nanocarrier for the highly efficient delivery of p53 gene to inh
The p53 gene has been widely investigated and considered to be an effective tumor suppressor in cancer gene therapy [1].......
A Comparison of the Effects of Linear and Branched Polyethylenimine on Inflammatory Mechanisms in Mo
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Controlling Fluorescence Emission from Oxygen-Doped Polyethylenimines and Its Potential for Gene Del
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Dendrimers have been extensively explored as non-viral vectors due to their inherent advantages including well-defined m......
Introduction of an AIE fluorophore into cationic gene delivery vehicles verified the nuclear translo
Gene therapeutic approach rooted in the concept of engineering nanoparticulates as gene delivery vehicles to accommodate......
One-step gene delivery into cytoplasm in a fusion-dependent manner based on a new membrane fusogenic
In the past two decades,gene therapy has shown promising potential to treat a variety of diseases,such as cancer,viral i......
Gene therapy has been explored as a treatment strategy for diverse disease.Various gene carrier systems including viral,......
Though great attention has been paid in constructing well-defined nano-structures via the self-assembly of amphiphilic m......
We have been exploiting inherent tumor properties in the delivery of anticancer therapeutic materials and aimed specific......
Fluorocarbon chains are both hydrophobic and lipophobic.Modification of polymers with fluorocarbon chains improves their......
Polyethylenimines modified by amino acids with different charge states and hydrophilic/hydrophobic p
Gene therapy appears to be a promising method in cancer therapy.Gene carrier is an essential factor for a successful gen......
Polyrotaxane Supramolecular Derivative Architectures:Syntheses Structures and Application for Drug a
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Thermoplastic,biodegradable elastomers have been developed using polyurethane chemistry with a variety of soft segment d......
Recombinant DNA technology provides the opportunity to synthesize monodisperse protein-based polymers with precise seque......
C-Jun Gene-Modified Schwann Cells:Upregulating Multiple Neurotrophic Factors and Promoting Neurite O
Genetic modified Schwann Cells(SCs)over-expressing neurotrophic factors(NFs),especially those with multiple NFs over-exp......
